Artificial Sweeteners: Are They Safe or Secretly Harmful? | Evidence-Based Insights
- Dr Meghanath Yenni
- Apr 12
- 1 min read
Explore the science behind artificial sweeteners like sucralose and aspartame. Learn how they may impact appetite, weight gain, and metabolic health—based on the latest research published in Nature Metabolism, BMJ, and Circulation.

Artificial Sweeteners: Are They Sweet Deceivers?
#Artificialsweeteners—such as sucralose, aspartame, and saccharin—are marketed as healthier alternatives to sugar. However, emerging science suggests these "zero-calorie" substitutes may not be as benign as once believed.
A recent study in Nature Metabolism (2025) found that sucralose enhances brain responses to food cues, possibly increasing appetite and calorie consumption, contradicting its intended purpose. Meta-analyses from leading journals like BMJ and Circulation have linked chronic use of #artificialsweeteners to #metabolicsyndrome, weight gain, #type2diabetes, and #cardiovasculardisease.
While regulatory bodies still approve their use, it is increasingly evident that the long-term health implications warrant caution. As clinicians and informed individuals, promoting naturally sweet whole foods over ultra-processed “diet” options may offer a safer path to metabolic health.
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